Publications

  • Ambati, J., Narendren, S., Pereira, F., et al. Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration Nature.com April 2021
  • Fukuda S., Varshney A., Fowler BJ., et al. Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration. Proceedings of the National Academy of Sciences (PNAS) - 2021; 118(6): e2022751118.
  • Ambati, J. Magagnoli, J., Leung, H. et al. Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development Nat Commun 11,4737 (2020). https://doi.org/10.1038/s41467-020-18528-z
  • De Cecco M, Ito T, Petrashen AP, et al. L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature  2019; 566:73-8.
  • Kerur N, Fukuda S, Banerjee D, et al. cGAS drives non-canonical NLRP3 inflammasome in age-related macular degeneration. Nature Medicine 2018; 24:50-61.
  • Al-Khalidi R, Panicucci C, Cox P, et al. Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism. Acta Neuropathologica Communications 2018; 6:27.
  • Mizutani T, Fowler BJ, Kim Y, et al. Nucleoside reverse transcriptase inhibitors suppress laser-induced choroidal neovascularization in mice. Investigative Ophthalmology & Visual Science 2015; 56: 7122-9.
  • Gelfand BD, Wright C, Kim Y, et al. Iron toxicity in the retina requires Alu RNA and the NLRP3 inflammasome. Cell Reports 2015; 11:1686-93.
  • Fowler BJ, Gelfand BD, Kim Y, et al. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science 2014; 346:1000-3.
  • Kim Y, Tarallo V, Kerur N, et al. DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration. Proceedings of the National Academy of Sciences 2014; 111:16082-7.
  • Kerur N, Hirano Y, Tarallo V, et al. TLR independent and P2X7 dependent signaling regulates Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Investigative Ophthalmology & Visual Science 2013; 54:7395-401.
  • Tarallo V, Hirano Y, Gelfand BD, et al. Loss of DICER1 loss and Alu RNA induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88. Cell 2012; 149: 847-59.
  • Kaneko H, Dridi S, Tarallo V, et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature 2011; 471: 325-30.